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Central administration of palmitoylethanolamide lessens hyperalgesia in mice via inhibition of NF??B nuclear signalling in dorsal root ganglia. Eur J Pharmacol?acylethanolamines (NAEs), endogenous biologically Lively lipids including the endogenous cannabinoid receptor ligand anandamide as well as satiety variable oleoylethanolamide. PEA was determ